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Most common sites of action, and action exerted at those sites (excitatory/inhibitory/modulatory?)
GABAnergic neurons in central nervous system - generally inhibitory. Is the major inhibitory neurotransmitter in the CNS.
Medium spiny cells act as inhibitory GABAergic cells in CNS.
Acts excitatory in insects and activates synapses between nerves and muscles.
(hippocampus and neocortex) - excitatory effects
, regulates growth of neural and embryonic stem cells.
Receptors (type, differences in signaling depending on receptor?)
GABA receptors(Gaba A and Gaba B)
GABA A= ligand gated ion channel (ionotropic)
GABA B = metabotropic
Mechanism to stop signaling
Reuptake by presynaptic cell
Inhibition of GABA receptors with antagonist.
Behavioral outcomes of release
anti-anxiety, relaxation, anti-convulsive effects
Drugs that act on this system (where? what do they do? what is the behavioral outcome?)
Agonists = alcohol, benzodiazepines
Antagonists = flumazenil
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