GABA

Neurotransmitter family

Amino Acid

Most common sites of action, and action exerted at those sites (excitatory/inhibitory/modulatory?)


GABAnergic neurons in central nervous system - generally inhibitory. Is the major inhibitory neurotransmitter in the CNS.
Medium spiny cells act as inhibitory GABAergic cells in CNS.
Acts excitatory in insects and activates synapses between nerves and muscles.
(hippocampus and neocortex) - excitatory effects during development, regulates growth of neural and embryonic stem cells.

Receptors (type, differences in signaling depending on receptor?)


GABA receptors(Gaba A and Gaba B)
GABA A= ligand gated ion channel (ionotropic)
GABA B = metabotropic

Mechanism to stop signaling


Reuptake by presynaptic cell
Inhibition of GABA receptors with antagonist.

Behavioral outcomes of release


anti-anxiety, relaxation, anti-convulsive effects

Drugs that act on this system (where? what do they do? what is the behavioral outcome?)


Agonists = alcohol, benzodiazepines
Antagonists = flumazenil