Opioids


Endogenous transmitters


Enkephalins
Endorphins
Dynorphins

Neurotransmitter family


Neuropeptides

Most common sites of action, and action exerted at those sites (excitatory/inhibitory/modulatory?)

Limbic and hypothalamic areas of the brain
Central nervous system- inhibitory (relieves pain)
Peripheral nervous system- inhibitory
Gastrointestinal tract


Receptors (type, differences in signaling depending on receptor?)


μ- endorphins, analgesia, reinforcement, cardiovascular and respitory depression, vomiting
ϰ- dynorphins, water balance, feeding temperature control, dysphoria
δ- endorphins, cognitive function, reinforcement, analgesia

Mechanism to stop signaling

Peptides broken down in the synapse.

Behavioral outcomes of release

Sensory
Emotional
Cognitive

Drugs that act on this system (where? what do they do? what is the behavioral outcome?)

Morhpine - Analgesia, Sedation, Euphoria, Constipation, Tolerance, Addiction, Withdrawl