Most common sites of action, and action exerted at those sites (excitatory/inhibitory/modulatory?)
Frontal cortex, striatum, substantia nigra, hippocampus, raphe nuclei, nucleus accumbens
Excitatory, inhibitory, modulatory (large receptor family)
Receptors (type, differences in signaling depending on receptor?)
Serotonin (5-HT) receptors, which are G-protein coupled, ligand-gated ion channels
Mechanism to stop signaling
Behavioral outcomes of release
increases body temperature
Drugs that act on this system (where? what do they do? what is the behavioral outcome?)
DMT, mescaline, LSD, MDMA all target serotonin reuptake. MDMA causes more release of serotonin.
selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOs) function similarly
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