Serotonin

Neurotransmitter family

Small molecule

Most common sites of action, and action exerted at those sites (excitatory/inhibitory/modulatory?)

Frontal cortex, striatum, substantia nigra, hippocampus, raphe nuclei, nucleus accumbens
Excitatory, inhibitory, modulatory (large receptor family)


Receptors (type, differences in signaling depending on receptor?)

Serotonin (5-HT) receptors, which are G-protein coupled, ligand-gated ion channels


Mechanism to stop signaling

Reuptake


Behavioral outcomes of release

regulates sleep
improves mood
suppresses appetite
increases body temperature

Drugs that act on this system (where? what do they do? what is the behavioral outcome?)

Psychedelic drugs:
DMT, mescaline, LSD, MDMA all target serotonin reuptake. MDMA causes more release of serotonin.

Anti-depressants:
selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOs) function similarly